Additional Information

Int Journal of Oral and Maxillofacial Surgery 2006 Mar 25;

In vivo and in vitro degradation of a novel bioactive guided tissue regeneration membrane.

Nieminen T, Kallela I, Keranen J, Hiidenheimo I, Kainulainen H, Wuolijoki E, Rantala I.

Department of Pharmacological Sciences, Medical School, University of Tampere, Finland.

The aim of this study was to assess degradation of a novel bioactive guided tissue regeneration (GTR) membrane and to quantify the concurrent tissue responses. Pieces of membrane composed of poly-l-lactide, poly-d,l-lactide, trimethylenecarbonate and polyglycolide were dipped into an N-methyl-2-pyrroline (NMP) solution and implanted in the mandibles of 10 sheep. The animals were sacrificed at 6-104 weeks. Parallel in vitro degradation was analysed by measuring the inherent viscosity, water absorption and remaining mass. One of the 2 in vitro sets of membranes was prehandled with NMP. At 6-26 weeks in vivo, the gradually more degraded implants were surrounded by a fibrous network. At 52 and 104 weeks, the implants and fibrous networks were non-detectable. Foreign body granulomatous reactions were not observed. In vitro, the mass of the NMP-exposed membranes diminished linearly over the 2-year period down to 10%, while the non-NMP-exposed membrane maintained all their mass for the first 16 weeks. The membranes without NMP had absorbed significantly less water at weeks 4 and 8 than the other group. The inherent viscosity decreased relatively uniformly in the in vitro groups. In conclusion, the in vivo degradation was complete in 12 months with only mild histologic responses; the degradation in vitro may be slower. NMP accelerates the degradation.

A new bioresorbable membrane in Augmentation Surgery, D Bilk.pdf (110.52 kilobytes)

Space to Grow, A Bendkowski.pdf (2.76 megabytes)

A video by Dr. Anthony Bendkowski. " Placement of three implants in the upper anterior region & Concurrent particulate bone augmentation - Featuring
Inion GTR Biodegradable Membrane System"

Membrane download.asf (23.72 megabytes)

Article at Global Surgery 2004 by Dr Joey Heinze, University of Oklahoma, USA
" A Space-maintaining Membrane for Guided Tissue Regeneration"

GTR Membrane.pdf (1.51 megabytes)

Poster: " Structural characterization of porous bioactive 3-D glass fibre scaffolds for tissue engineering applications" poster2-bis.pdf

The scientific publication "THE FIRST BIOACTIVE, DEGRADABLE GUIDED BONE REGENERATION" by FE Weber et al. was orally presented at the IADR Annual Meeting in Göteborg held in June 2003.

Poster: " Development of a novel membrane for guided tissue/bone regeneration"